599 The compendium of profiling coding and non-coding RNAs in human skin wounds

Wound healing is a complex and well-orchestrated process to keep our skin intact. This delicate repair often gets disrupted in patients with underlying causes. However, the effective wound therapy lacking due limited knowledge of related molecular pathogenesis. In this study, we performed paired small RNA (miRNA) long (circular mRNA) sequencing human tissue samples, including matched acute wounds collected at each stage (Day 1 Day 7) chronic non-healing venous ulcers (VU). Based on these transcriptomic data, developed two user-friendly compendia deployed server (miRNA Shiny app: https://www.xulandenlab.com/humanwounds-mirna-mrna, circRNA https://www.xulandenlab.com/humanwounds-circrna), which will be an open, comprehensive resources broadly aid research. resources, visualized easily single expression changed patterns miRNA, mRNA acoross different conditions. addition, also identified several circRNAs miRNAs, can perturb cellular processes inflammation, migration, proliferation healing. Findings study provide rich resource for developing targets treating no-healing wounds.